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We observed significant correlations between the degree of basophil histamine release and the clinical parameters used in the diagnosis of drug-induced asthma including FEV1. We evaluated the diagnostic utility of the test in comparison with the measurement of the basophil cationic protein BasCp , the basophil cationic granulocyte chemotactic factor B-G-CSF , and the basophil cationic leukocyte migration inhibition test BCMLIT.
The evaluation of the diagnostic utility of the MT5-HT test showed that the presence of bronchospasm was a better discriminator than the degree of histamine release. The degree of histamine release can be estimated by a semiquantitative scoring system, which allows the classification of drug-induced asthmatic patients into three groups with different clinical sensitivity: sensitive, moderately sensitive and resistant. If you have any kind of issue please contact us.
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